Genetic & genomic
LOVD
Leiden Open Variation Database
"Locus-specific variant databases, hosted on shared infrastructure."
About the resource
LOVD is the Leiden Open Variation Database — both an open-source software platform and a hosting service. It powers hundreds of locus-specific databases (LSDBs), where expert curators for an individual gene or gene family share variants, phenotypes and submitting-lab metadata for inherited disease.
LSDB content is the bedrock of variant interpretation for many gene-specific communities (the DMD/DYSF database, the CFTR2 project, the MITOMAP and ABCA4 archives all share its lineage). LOVD instances can be local to a centre or federated through a global directory.
What you'd use it for
- 01Find the curator's database for a specific disease-gene of interest
- 02Submit novel variants to the relevant gene-specific community
- 03Run a federated search across LOVD instances
- 04Stand up an in-house LSDB for a newly characterised gene
How you access it
LOVD web UI per LSDBVCF exportFederated search via LOVD lookup service