Somatic mutation catalogues, multi-omic cohort atlases, precision-oncology knowledge bases and population surveillance — the data infrastructure of cancer research and treatment.
The world's most comprehensive resource for somatic mutations in human cancer, drawing on tens of thousands of publications and large studies. Includes the Cancer Gene Census, Mutational Signatures, Cancer Mutation Census and Actionability resources.
A landmark NCI/NHGRI program that characterised more than 20,000 primary tumors and matched normals across 33 cancer types using multi-omics, with data accessible through the GDC (Genomic Data Commons) and downstream portals.
Originally developed at MSK, provides interactive web-based exploration of large cancer genomics datasets (TCGA, MSK-IMPACT and many others), with visual tools for mutations, copy number, expression, methylation, clinical data and survival.
The International Cancer Genome Consortium aggregates cancer genome data across countries; the Pan-Cancer Analysis of Whole Genomes (PCAWG) extended this to whole-genome sequences of more than 2,800 cancers, with strong coverage of noncoding and structural variation.
Precision-oncology knowledge bases curating the clinical significance of cancer variants — therapeutic, diagnostic and prognostic implications. CIViC is open and community-edited; OncoKB is FDA-recognised in part.
Operated by NCI, provides authoritative U.S. cancer incidence, prevalence, survival and mortality statistics — the primary epidemiology source for U.S. cancer research.
The International Agency for Research on Cancer produces GLOBOCAN (global cancer incidence and mortality estimates), CI5 (Cancer Incidence in Five Continents) and the IARC Monographs on carcinogens — essential global cancer references.