Cancer databases
ICGC / ARGO / PCAWG
International Cancer Genome Consortium
"International cancer-genome consortia — including the PCAWG whole-genome atlas."
About the resource
The International Cancer Genome Consortium (ICGC) launched in 2008 as the international complement to TCGA, coordinating projects across roughly 20 countries. The Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium extended this to whole-genome sequences of more than 2,800 tumors across 38 cancer types, producing the landmark 2020 Nature 'pan-cancer' papers on driver discovery, mutational signatures, structural variation and noncoding mutation.
ICGC ARGO, the consortium's current iteration, aims for clinically annotated whole-genome cancer data on hundreds of thousands of patients, with cloud-based federated analysis. Access to controlled-tier data requires Data Access Compliance Office (DACO) approval.
What you'd use it for
- 01Analyse noncoding and structural variation across cancer types
- 02Extend a TCGA analysis with international cohorts
- 03Pull the PCAWG mutational-signature derivations as a reference
- 04Apply for DACO access to ICGC-ARGO controlled data
How you access it
DCC portalCloud workspacesPCAWG release files