Cancer databases
OncoKB & CIViC
Precision-oncology knowledge bases
"What a cancer variant means for therapy, prognosis and diagnosis."
About the resource
OncoKB is Memorial Sloan Kettering's precision-oncology knowledge base. Each variant–cancer entry carries a level of evidence — FDA-approved therapy, standard-of-care guidance, compelling clinical evidence, biological evidence — and is curated by a clinical team. OncoKB is partially FDA-recognised as a Human Variant Database under 21 CFR 866, the first such recognition for a public oncology knowledge base.
CIViC, developed at Washington University in St. Louis, is the open, community-edited counterpart with a similar but more granular evidence model. Both are widely used inside molecular-tumor-board workflows and inform commercial precision-oncology pipelines. OncoKB is registration-tiered; CIViC is fully open under CC0.
What you'd use it for
- 01Annotate a cancer variant with therapy, diagnosis and prognosis implications
- 02Run a molecular-tumor-board workflow over a sequencing report
- 03Pull CIViC evidence into an open clinical-decision-support pipeline
- 04Use OncoKB levels-of-evidence to triage actionable findings
How you access it
Web UIREST APIBulk downloads (CIViC: CC0; OncoKB: tiered licence)