Genetic & genomic
PharmGKB
Pharmacogenomics Knowledge Base
"Pharmacogenomic variant–drug relationships and CPIC dosing."
About the resource
PharmGKB is the Stanford-led pharmacogenomics knowledge base. It curates relationships between genetic variants and drugs — efficacy, dosing, toxicity, metabolism — along with star-allele definitions for pharmacogenes (CYP2C19, CYP2D6, TPMT, HLA-B, SLCO1B1 and many others), drug-label annotations from FDA, EMA, PMDA, Swissmedic and HCSC, and clinical dosing guidelines from CPIC, DPWG and CPNDS.
It is the principal resource for precision-medicine work on adverse drug reactions and treatment response, and is integrated into many clinical decision-support implementations of pharmacogenomic testing.
What you'd use it for
- 01Look up CPIC dosing guidance for a CYP2C19 metabolizer phenotype
- 02Find the star-allele definitions for a pharmacogene
- 03Audit FDA drug-label annotations for genetic information
- 04Build clinical decision support around pharmacogenomic testing
How you access it
Web UIREST APIBulk downloads (PGx vocabularies)