Specialty disease databases
ADNI
Alzheimer's Disease Neuroimaging Initiative
"The defining longitudinal Alzheimer's neuroimaging cohort."
About the resource
The Alzheimer's Disease Neuroimaging Initiative (ADNI), launched in 2004 as a public-private partnership and now in its fourth phase, has assembled one of the most comprehensive longitudinal datasets on Alzheimer's disease and related dementias. Participants undergo serial MRI and amyloid/tau PET imaging, CSF and blood biomarker measurement, neuropsychological assessment and genetic profiling, with follow-up over years.
ADNI data have powered thousands of papers — from amyloid-PET prognostic models to plasma p-tau biomarker validation — and are accessed through the Laboratory of NeuroImaging (LONI) under data-use agreement. Complementary cohorts include AIBL, DIAN (dominantly inherited AD), A4 and the global Alzheimer-disease platforms.
What you'd use it for
- 01Train and validate Alzheimer's-progression models on multi-modal imaging
- 02Validate plasma p-tau or other biomarker assays against AD endpoints
- 03Run amyloid-PET trajectory analyses across cognitive states
- 04Pair ADNI with DIAN or AIBL for cross-cohort replication
How you access it
LONI image and data archiveBulk imaging downloadsCloud-hosted via AWS for selected cohorts