Drug & chemical–disease
Comparative Toxicogenomics Database
CTD — chemicals, genes, diseases
"Chemicals, genes, phenotypes and diseases — the curated environmental-health graph."
About the resource
The Comparative Toxicogenomics Database (CTD) at North Carolina State University manually curates interactions between chemicals, genes and proteins, and inferred relationships to diseases and phenotypes, from the published literature. Its core data model covers chemical–gene, chemical–disease and gene–disease interactions with direction and tissue context, plus a chemical–phenotype dataset built on the MEDIC ontology.
CTD is the leading public resource for toxicogenomics and environmental-health research and is widely used for chemical–disease hypothesis generation and chemical-exposure annotation. Monthly releases; CC-BY-NC-SA.
What you'd use it for
- 01Find candidate environmental exposures linked to a disease
- 02Annotate genes with chemical-perturbation evidence
- 03Hypothesise gene–disease relationships via shared chemical interactions
- 04Power toxicogenomic data-integration pipelines
How you access it
Web UIBulk downloadsREST API