TTD & Open Targets
About the resource
The Therapeutic Target Database (TTD) is a long-standing catalogue of known and explored therapeutic targets, indications, drug pharmacology and biomarkers, maintained at the IDRB Lab at Zhejiang University. It is widely cited as the canonical target-list reference.
Open Targets — the EMBL-EBI, Wellcome Sanger Institute, Bristol Myers Squibb, GSK and other partner consortium — extends the model with quantitative target–disease association scoring across genetics (GWAS, gene-burden), somatic mutation (TCGA, COSMIC), drug data (ChEMBL, FDA), pathways, text mining and animal models. Its Open Targets Platform is one of the most-used open target-prioritisation resources in industrial and academic drug discovery, and the Open Targets Genetics portal layers in GWAS-locus-to-gene methods. CC0.
What you'd use it for
- 01Prioritise drug targets for a disease across integrated evidence
- 02Find existing drugs targeting a candidate gene in any disease
- 03Audit the genetics-to-gene assignment for a GWAS locus
- 04Pull target-evidence data into a custom prioritisation pipeline